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As the time point of the highest concentration (Tmax) in simulations can differ from the reported Tmax, predicted and observed concentrations were compared at the in vivo Tmax.
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The Cmax (highest peak concentration), Tmax (the time at which Cmax reached), and the AUC0-∞ (the total area under the curve) were determined.
The maximum plasma concentrations (Cmax) and time to maximum plasma concentrations (Tmax) were determined from the highest concentration, and the time of at which it was observed.
Maximum serum concentration (Cmax), area under the serum concentration time curve (AUC), time to maximum serum concentration (tmax) and elimination half life (t1/2) where feasible, were calculated.
Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the urine concentration time curve.
Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the plasma concentration time curve.
Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the serum concentration time curve.
Maximum concentration (Cmax) and time to maximum concentration (tmax) were taken directly from the observed data.
The maximum concentration (Cmax) and the time to reach peak concentration (tmax) were the observed values.
Cmax: maximum concentration, Tmax: Time needed to reach the maximum concentration, AUC: area under curve.
Cmax = maximum concentration; Tmax = time to maximum concentration; T1/2 = half-life.
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