Sentence examples for maximal stimulatory effect from inspiring English sources

In the present study, 200 nM of ET-1 showed the maximal stimulatory effect on type I collagen expression in normal human dermal fibroblasts.

The maximal stimulatory effect was observed for concentrations of 5 10 ng ml−1 for both cell lines (+30%, P<0.001).

The concentration of G-actin required to elicit a half maximal stimulatory effect was similar for both complexes, <100 nM, whilst an irrelevant protein, bovine serum albumin had no stimulatory effect on eIF2aP dephosphorylation.

The increase of PI3K activity associated with p85 regulatory subunit in response to ATP was comparable in magnitude to the effect of 10% fetal bovine serum, used in our experiments as a positive control to evaluate the maximal stimulatory effect.

However simultaneous mutation of both sites produced an AC2 variant that was insensitive to PMA stimulation, which suggested that phosphorylation of both Ser or Ser is required to achieve the maximal stimulatory effect of PKC.

In order to analyze the proliferative effects induced by CXCR4 activation, the obtained mammary carcinoma primary cultures were starved for 24 h and treated with 25 nM SDF-1 for further 24 h (the concentration was chosen as the maximal growth stimulatory effect obtained in previous experiments on human breast cancer cell lines [ 19]), and then MTT cell viability assays were performed.

The invasive stimulatory effect of the maximal invasive dose of SDF-1, 15 ng ml−1 (titration data not shown), was compared to the invasive stimuli from BMECs and primary BMS with or without 10  μg ml−1 T140 (concentration required to inhibit completely SDF-1 signalling in prostate epithelial cells (titration data not shown)).

27 We used 1 ng/ml IL1α and 2.5 mg/ml HA species (except for HAoligo), as these concentrations of IL1α and HA showed a definite stimulatory effect on ADAMTS4 expression and a maximal inhibitory effect on IL1α-induced ADAMTS4 expression, respectively (data not shown).

Indeed, the model predicts that tamoxifen < 50 nM will have a stimulatory effect on ER-dependent transcription in cells with ER level lower than 80 nM, with anticipated maximal agonism for medium ER expression levels (10 30 nM ER, areas 1 and 2).

"Monetary policy is already expansionary and I'm doubtful that an even more expansionary stance would have stimulatory effect at all," Weidmann said.

Arrows indicate a stimulatory effect.