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With high local concentrations and minimal distribution to other organs via the circulation, topical applied MBGs loaded with Cyclosporin A might deliver maximal therapeutic effect to local tissue while avoiding the side effects seen with systemic therapy.
With high local concentrations and minimal distribution to other organs via the circulation, topical microemulsion vehicle loaded with CysA might deliver maximal therapeutic effect to local tissue while avoiding side effects seen with systemic therapy.
To achieve maximal therapeutic effect.
Prescriptions for Chinese medicine usually combine several herbs or other ingredients to gain the maximal therapeutic effect.
The mechanical properties of the materials including the abilities of force-distribution, shock absorption and durability should be considered thoroughly to achieve the maximal therapeutic effect [ 11, 12].
The dose was titrated to maintain the valproate level at around 100 mEq/L and lithium at 1 mEq/L for expected maximal therapeutic effect.
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Therapeutic stretching is the most commonly applied treatment for adhesive capsulitis, but optimal stretching postures for maximal therapeutic effects on the CHL have not been fully investigated.
These results suggest that membrane-bound protease activity may play a critical role in airway damage and that NE and MMP12 may have to be inhibited at the surface of inflammatory cells to achieve maximal therapeutic effects.
To achieve the maximal therapeutic effects, nucleofection reagents were modified to improve gene transfection efficiency in primary cell cultures of fibroblasts (details described in Materials and Methods).
To obtain maximal therapeutic effects, the prolonged and continuous administration is required.
The 1 mg/kg, q4dx3 treatment schedule for SGN-35 was selected based on previous reports demonstrating maximal therapeutic effects at a q4dx4 schedule (Francisco et al, 2003).
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