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Moreover, there was a significant correlation between the concentration of NO derivatives and the percentage of maximal fall in FEV1 (r = 0.569, P =.019).
The change in the concentration of NO derivatives was significantly correlated with the change in the AUC0-30 (r = 0.896, P =.0114) but not with the change in the percentage of maximal fall in FEV1.
Interestingly, however, the intermediate nitrate dose tested caused the maximal fall in Hb, with the anemic response partially reversed on supplementation with 1.4 mM NaNO3.
The primary safety outcome, mean maximal fall in haemoglobin concentration during 28 days of follow-up will be assessed for each treatment arm.
The magnitude of attenuation of the LAR is not directly comparable to the previous study involving the orally administered PDE4 inhibitor roflumilast, which inhibited the maximal fall in the EAR and LAR by 14-28% and 16-43% respectively [ 10, 28].
Secondary efficacy outcome measures (all at Week 13) were EAR, defined as the AUC of FEV1 0–2 h following allergen challenge, the maximal fall in FEV1 that occurred 0 2 h following challenge, methacholine challenge PC20, and change in methacholine challenge PC20 relative to the PC20 observed 24 h following allergen challenge at screening.
Similar(54)
Elafin levels at day 4 post-infection were inversely related to maximal falls in PEF.
Elafin levels at day 4 post-infection were inversely related to maximal falls in PEF (r = −0.761, P = 0.017) in asthmatics (Fig. 2c).
This postulation is in accordance with the maximal fall of systolic blood pressure and heart rate, observed throughout the post-drug periods.
LVdP/dt in the control IR group remained significantly depressed throughout the entire ischemic and reperfusion duration, the maximal fall was recorded at the end of the reperfusion period (p < 0.001) as compared to sham.
Our model predicts that the optimal radius of NPs for maximal uptake rate falls in the range of 25 30 nm, and optimally several tens of ligands should be coated onto NPs.
Related(20)
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