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The high-dose saquinavir regimen (7200 mg/d) produced a mean maximal decrease in the plasma HIV RNA level of 1.34 log RNA copies/mL of plasma and a mean maximal increase in CD4 count of 121 cells/mm3.
A maximal decrease in expression of CD15 was observed in HG females on P9, coinciding with maximal change in their cerebellar mass.
A maximal decrease in expression of GFAP was observed in HG males on P6, coinciding with maximal change in their cerebellar mass.
There is a maximal decrease in liver SI with most T2-weighted sequences.
Results The mean pre-induction WBC count was 15.1 ± 12.2 x 109 L; 91.7 % of patients experienced a decrease in WBC count after induction with a mean maximal decrease in white cell count of 9.15 x 109 L.
This effect was not observed for the labelling of DTPA-exendin-3 in MES and HEPES with a maximal decrease in SA of 10% and 4% at day 11, respectively.
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Maximal decreases in diastolic blood pressure occurred at 1 hour when assessed on days 1 and 15 (16.0, 17.4, and 15.8 mm Hg, vs 17.2, 18.7, and 17.5 mm Hg, respectively).
Maximal decreases in neutrophil counts occurred at day 15 after cycle 6 in both groups.
The maximal decreases in the IC50 were 80-fold for 5-FU and 40-fold for 5′-DFUR.
Maximal decreases in IYFP/ ICFP (Δmax) triggered by patient or control IgG had similar ranges and medians.
Previous reports from studies using similar dosing protocols in rats demonstrated maximal decreases in figure-eight maze activity at 1 4 hr postdosing (Crofton et al. 1995; Crofton and Reiter 1984, 1988; McDaniel and Moser 1993; Wolansky et al. 2006).
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