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Objective To assess the maturation of auditory evoked cortical responses in the human fetus using fetal magnetoencephalography.

In the mouse, deficits in IGF-I result in profound hearing loss associated with reduced survival, differentiation and maturation of auditory neurons.

Accordingly, the Igf1−/− mouse shows poor growth rates, high mortality, profound sensorineural deafness and late postnatal morphological alterations in the cochlea [16] We have shown previously that the absence of IGF-I causes poor myelination and delayed maturation of auditory neurones that suffer apoptosis during the early postnatal mouse development P5-P20 [18], [18].

Synaptic inhibition (GABA) and excitation (glutamate) are considered to be central regulators in the maturation of auditory response properties, and continue to be intensively studied [ 16– 20].

The decrease in the amplitude and latency of P1 is also said to reflect the decline in synaptic density and increased intracortical myelination (Ceponiene et al., 2002b) and maturation of auditory pathways (Sharma et al., 2002).

In the auditory system of altricial animals, neuronal activity increases markedly after the opening of the ear canals, initiating events that culminate in the maturation of auditory circuitry in the brain.

Similar(52)

Electrical stimulation by a cochlear implant (CI) induces maturation of the auditory system and reorganization of the auditory cortex in deaf children.

More generally, the memory traces of the fetus' auditory environment in which early maturation of the auditory system occurs can result in the infants' differential responding to specific stimuli.

Cortical auditory evoked potentials are a non-invasive tool that can provide objective information on maturation of the auditory pathways.

In congenitally deaf children fit with a cochlear implant, little is known about the maturation of the auditory cortex.

Conclusion: In order to shorten the process of central maturation of the auditory system, it is desirable to implant the children as young as possible.

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