Sentence examples for maturation and refinement from inspiring English sources

This is because system-based methods are still in a stage of maturation and refinement.

Notwithstanding its success in explaining the maturation and refinement of downstream circuits and sensory maps, our understanding of the underpinnings of this developmental model is still far from complete.

Around the time of eye opening, there is a period of intense synapse formation that gradually gives way to processes involved in synapse maturation and refinement, including synapse elimination.

DOI: http://dx.doi.org/10.7554/eLife.04047.019 Synaptic maturation and refinement, wherein appropriate synapses are strengthened while superfluous connections are eliminated, are critical for the establishment of functional neuronal circuitry.

Our observation is in line with numerous studies showing that the maturation and refinement of corticospinal pathways crucially depends on motor behaviour and the neural activity it elicits in early life (Eyre, 2007; Martin et al., 2007).

Mice lacking SynI, SynII, SynI/II or SynI/II/III are all prone to epileptic seizures starting at an age of 2 3 months [22,24,45], a period of intense synapse maturation and refinement in which Syns I/II have already reached high expression levels [46,47].

These crucial processes of cortical brain maturation and functional refinement may be implicated in juvenile myoclonic epilepsy.

First and foremost, essentially every stage of normal neural development, from neurogenesis and differentiation to axon pathfinding, synapse maturation and circuit refinement, has been studied in detail in Xenopus tadpoles (Cline and Kelly, 2012; Sanes et al., 2012).

Conceptually, this will require the development and refinement of models of adolescent brain development that address specific aspects of pubertal maturation (e.g. specific hormones) that are causally linked to specific aspects of brain and behavioral changes.

49, 50 These processes of cortical brain maturation and ongoing functional refinement of cortical networks may be critical processes where abnormalities of network function or abnormalities within gene expression pathways may lead to epilepsy or its comorbidities.

These authors found a reduction in overall mortality rates after system introduction, but the effect did not appear for 10 years, suggesting that the results related to maturation of the trauma system and refinement of policies and referral patterns.