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Fractional anisotropy (FA), an index of white matter integrity, is highly heritable but the genetic architecture of this trait has received little investigation.
Diffusion tensor imaging (DTI), a magnetic resonance imaging (MRI) technique that investigates white matter integrity, is recognized as a useful tool to quantify DAI extent in TBI and possibly predict outcome.
A technique that has gained remarkable popularity in the past ten years as means for studying white matter integrity is Diffusion Tensor MRI (DTI), used to image, in vivo, the diffusion of water molecules in brain tissue.
Alternatively, it would be useful to know if WM correlations with face and scene oddity hold up when you control for the influence of size oddity performance (i.e. this would show that white matter integrity is predictive of face/scene oddity over and its contribution to lower level visual discriminations).
The presence of early changes in subcortical grey matter integrity is consistent with the early subcortical amyloid deposition observed in familial AD, and serves to emphasize that it is not only cortical grey matter that is affected early in the disease process [ 40, 41].
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White matter integrity was quantified using a widely accepted measure, fractional anisotropy (FA).
We recruited 45 6-year-old girls based on whether they had previously shown high or low cortisol reactivity to a stress task at age 3. White matter integrity was assessed by calculating fractional anisotropy (FA) of diffusion-weighted magnetic resonance imaging scans.
Evidence of putatively reduced white matter integrity was found in the rostral body and isthmus of the corpus callosum.
Our main research question was whether age-related changes in white matter integrity are associated with age-related increases in rates of word retrieval failures.
This relationship provides evidence consistent with the hypothesis that compromised white matter integrity was related to functional impairment in decision making.
Finally, we turn our attention to the main question we set out to answer with this study: whether age-related changes in white matter integrity are associated with age-related increases in rates of word retrieval failures.
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Justyna Jupowicz-Kozak
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