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To conclude that white matter integrity has a mediating (causal) contribution, it is necessary to demonstrate that statistical control of the white matter-cognition relation reduces the magnitude of age-cognition relation.
Reduction in fornix white matter integrity has typically been associated with episodic memory (Metzler-Baddeley et al., 2012).
This is surprising as loss of white matter integrity has been suggested as a key component of psychotic disorders (McGuire and Frith, 1996).
White matter integrity has been shown to be important for cognitive performance, but very few studies have taken this into account when investigating the effects of IR in animal models.
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Reduced numbers of dopamine receptors, impaired cognitive functioning and compromised white matter integrity have also been noticed in cases of screen time overuse.
These correlations are universally negative, i.e., individuals with greater white matter integrity have shorter RTs across a range of different cognitive tasks.
Consistent with our current findings, reductions in cingulum white matter integrity have also been associated with apathy in patients with dementia and in normal ageing (Cacciari et al., 2010; Kim et al., 2011; Hahn et al., 2013; Spalletta et al., 2013).
Precise explication of the mechanisms that govern differences in white-matter integrity has only begun to emerge as measures that distinguish these mechanisms in pathological and aging populations have been developed (e.g., Song et al. 2003; Nair et al. 2005; Bennett et al. 2009).
Cognitive impairment is common in Parkinson's disease (PD) and leads to patient suffering, caregiver burden and health-related costs. 1 Most imaging studies exploring brain changes associated with cognitive impairment in PD have focused on grey matter atrophy, whereas the importance of white matter (WM) integrity has been less explored.
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His integrity has been questioned.
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