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Proper folding of its triple helix is crucial for forming the matrix of bones and other tissues.
Picrosirius red staining shows the arrangements of collagen fibers in extracellular matrix of bones.
Demineralized matrix of bones and teeth, as prepared by several research groups, has been reported to produce bone in rodents.
Chemical treatment has been used attempting to remove the matrix of bones and teeth so as to obtain biological apatite.
Estrogen-related receptor alpha was found to affect transcription of an osteopontin gene promoter; osteopontin is an important constituent of the mineralized extracellular matrix of bones.
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It occupies a small chamber called a lacuna, which is contained in the calcified matrix of bone.
It is also an important cofactor in the enzymic processes that form the matrix of bone and in the synthesis of nucleic acid.
In scurvy, a disease caused by vitamin C deficiency, the collagen matrix of bone is either partially or completely unable to calcify (see above Remodeling, growth, and development).
Other nutritional factors include protein, which, as an essential component of the matrix of bone, must be provided by a combination of dietary intake and conversion from other tissues.
Although the researchers have not yet reached the stage of testing the material's strength in three dimensions, they have been able to show that, in the magnetised cells, the genes necessary for producing the matrix of bone are being stimulated.The researchers are now investigating the best conditions for growing bone, and whether this technique could be used to grow other types of tissue.
Electrospun nanofibers mimic the native extracellular matrix of bone and have generated considerable interest in bone tissue regeneration.
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