Sentence examples for matrix and activation from inspiring English sources

Combined our previous proteomics data with newly performed docking simulation, it indicated that the cell death induced by cRGD may be triggered through blocking integrin signaling to the extracellular matrix and activation of caspase pathway.

An EMT-like phenomenon, including degradation of extracellular matrix and activation of migratory pathways is also observed in cancer, and appears to be essential for metastases [ 88].

13 Indeed, IL-6 activates a whole cascade of events characteristic of inflammation, and leads to metalloproteinase-mediated degradation of cartilage matrix and activation of osteoclasts.

Thus, hyperglycaemia promotes the activation of protein kinase Cβ, and diabetic retinopathy/nephropathy develops and progresses through activation of vascular endothelial growth factor and accumulation of extracellular matrix and activation of transforming growth factor-β [ 8,18,26,27].

The role of Rho family proteins in cancer cell aggressiveness involves both cytoskeleton organization, which control several processes relevant to cell migration including adhesion of cells to the extracellular matrix, and activation of cell signaling processes leading to the activation of transcription factors.

The parameters A and B stand for carrier ion numbers in the matrices and activation energy for ion transport, respectively.

Various mechanisms play a role in the pathogenesis of DR, including the disruption of blood-retinal barrier, alterations to capillary vessel walls, synthesis of growth factors and nitric oxide, disruption of connective tissue by matrix metalloproteinases, and activation of various immune mechanisms.

Several studies have demonstrated the stimulation of TGFβ-mediated signalling results in increased production and accumulation of extracellular matrix proteins, and activation of protease inhibitors.

Here we know that the tumor microenvironment becomes mechanically stiff due to accumulation and reorganization of extracellular matrix proteins and activation of stromal fibroblasts.

The plasminogen system also plays an essential role in pericellular proteolysis-dependent degradation of the extracellular matrix (ECM) and activation of cytokines.

PAI-1 has a number of important roles in pathophysiological processes, such as inhibition of fibrinolysis, regulation of extracellular matrix turnover and activation of proenzymes and latent growth factors that promote tissue fibrosis and sclerosis [ 48].