Sentence examples for matrix and activate from inspiring English sources

The authors identify actin-rich filopod-like protrusions (FLP) that contain integrin and allow cells to attach to matrix and activate their prosurvival and growth pathways via focal adhesion kinase.

At micromolar concentrations, Ca2+ can also enter the intramitochondrial matrix and activate specific dehydrogenases.

After a fracture, BMPs growth factors diffuse from bone matrix and activate osteoprogenitor cells which, in turn, produce more BMPs [ 44 ].

Important regulators of these processes are MMPs and serine proteases that break down the extra-cellular matrix and activate plasminogen, respectively, resulting in a second wave of apoptosis and tissue remodelling [ 10].

Our data show that normal mast cells overexpressing miR-9 exhibit markedly increased HSPE expression, supporting the assertion that miR-9 may promote the metastatic phenotype by enhancing the proteolytic activity of a number of proteases important in physical remodeling of the extracellular matrix and activate mediators responsible for cell dissemination.

Plasmin is capable of degrading all the components of the extracellular matrix and activating other enzymes such as MMPs.

We also investigated variation in MMP9, as MMPs influence cancer progression and contribute to tumor angiogenesis, growth, and metastasis by degrading the extracellular matrix and activating growth factors [ 43].

Oxidative stress, overexpression of inflammatory cytokines, and retinal nutritional deficiency are some common mechanisms of AMD. 5 MSCs have various biological effects, 28 including secreting neurotrophins, promoting angiogenesis, regulating immune responses, inhibiting apoptosis, promoting extracellular matrix remodeling, and activating adjacent host stem cells.

So far, there is no treatment available for controlling the excessive activation of pancreatic stellate cells, which mainly produce the extracellular matrix and which activate themselves in an autocrine loop by secreting pro-fibrogenic molecules such as TGFbeta and by producing pro-inflammatory cytokines.

Angiogenic factors from tumours induce and activate matrix metalloproteinase, plasminogen activator, collagenase and other enzymes in endothelial cells (ECs).

On the one hand, chemoattractants administered via microinjection into a perivascular region of the interstitium may diffuse through the extracellular matrix and directly activate the endothelium on the ipsilateral vessel side via G-protein-coupled receptors (GPCRs) on endothelial cells.