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Under mixed-mode loading, the adoption through discretisation of Cohesive Zone Model as a bulk material (indicative of adhesive component) and to simulate interfacial cracks is shown here to achieve the objectives.
None of the vesicles appeared to be surrounded by electron dense material indicative of a clathrin coat, consistent with our immunoblotting data (Figure 1).
Common to all NCLs, both neuronal and peripheral tissues from JNCL patients show extensive accumulations of lysosomal storage material, indicative of some form of lysosomal dysfunction.
Moreover, an amorphous material indicative of accumulated lipid was also observed within these vacuoles as previously demonstrated by TEM within ML-containing phagosomes in Schwann cells (Mattos et al., 2011a).
Since access to human material indicative of the early initiating lesion is high or impossible to obtain, the question arises whether it is not possible to use an animal model system to gain insight into these key steps [129 133].
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Apparently, the accumulation of such 'waste' material is indicative of a catabolic insufficiency with respect to this material, but not of a general decline in autophagy.
The content and distribution of material was indicative of a complex mixture of building debris and combustion products in the resulting plume.
This region displays atypically high GC-content values and deviating GC-skew values compared with the neighboring segments (fig. 3 and supplementary fig. S3, Supplementary Material online), indicative of acquisition by horizontal gene transfer or strong compositional selection.
The ML analysis showed that VTI14 evolved much faster than its duplicated partner, VTI11 (fig. 5 A and supplementary fig. S6, Supplementary Material online), indicative of asymmetric rate evolution between VTI14 and VTI11.
Additionally, the distribution of substitution rates was notably wider for concatenated exons of mouse lincRNAs than it was for concatenated introns (fig. 1 and supplementary figure S1, Supplementary Material online), indicative of the variance in the intensity of the purifying selection on mouse lincRNA genes.
Thus the low coverage of these pathogens observed for the lead materials is indicative of the broad spectrum resistance to bacterial attachment achieved by this class of materials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com