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Exact(8)
In the first instance, treated male rats were mated with untreated females, followed by necropsy of a subset of males.
The remaining animals were mated with untreated sexually receptive females to evaluate the mating and pregnancy rates.
Once fertility was recovered, the animals were mated with untreated C57BL/6 J females to generate G1 offspring.
Adult male offspring (± 150 days of age; n = 15 19 animals/group), representing all litters, were mated with untreated females (1 1) daily for 14 days to determine whether the males were fertile and could sire normal offspring.
Evaluation of the F2 offspring from the F1 female offspring mated with untreated males revealed two anomalies in one pup (F2) from the 700-μg PBDE-47 group: a shortened mandible accompanied by fused tympanic bone.
When the litter mates of the animals analyzed for sperm counts were mated with untreated females for fertility studies, exposed males could sire offspring similar to the control males (Table 3).
Similar(52)
F1 male rats were maintained to generate F2 offspring by mating with untreated female rats.
Treated males were rested for 12 weeks before mating with untreated BALB/c females to produce G1 progeny.
At approximately 22 weeks of age, 22 24 female F1 offspring from each group were mated daily with untreated males for 14 days or until a sperm-positive vaginal smear was obtained.
Treated male rats which recovered from chemical castration and untreated controls were mated with breeder females.
Although some treated pupae at all doses eclosed (adjusted sterility of 66 74% depending on dose, where emerging adults are considered non-sterile), subsequent mating with untreated "wild-caught" males or laboratory-reared virgin females did not result in egg hatch, irrespective of dose rate (Fig. 2).
Related(16)
bred with untreated
fertilized with untreated
mated with uninfected
mated with normal
mated with multiple
mated with early
mated with grilled
mated with chive-dotted
mated with non-diabetic
mated with first-class
mated with other
mated with vasectomized
mated with sterilized
mated with naked
mated with tight
mated with wild
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