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Exact(5)
Since >1 PSC was identified for some patients, the analysis was repeated excluding PSCs with smear-negative results or extrapulmonary disease, and, if >1 PSC was smear-positive, choosing the most likely source of the infection by selecting the most closely matched strains and the closest contacts (e.g., contacts within the household were considered closer than nonhousehold contacts).
Importantly, vaccine efficacy did not wane as the influenza season progressed; the weekly cumulative vaccine efficacy from the beginning of March onward was >78% for antigenically matched A/H1N1 strains, >77% for all antigenically matched strains, and >70% for all strains, irrespective of antigenic match.
The weekly cumulative point estimate for vaccine efficacy was 71%82%% against cell culture confirmed infection with antigenically matched A/H1N1 strains, 73% 82% for cell culture confirmed infections with all antigenically matched strains, and 68%83%% for all cell culture confirmed infections, irrespective of antigenic similarity to the vaccine strains.
Vaccine efficacy was at least as high in the later stages of the study compared with earlier stages; the weekly cumulative vaccine efficacy from the beginning of March onward was >78% for antigenically matched A/H1N1 strains, >77% for all antigenically matched strains, and >70% for all strains, irrespective of antigenic match.
The cumulative vaccine efficacy estimates and efficacy up to or after 3 months reported here for the Vero-derived vaccine are similar to those determined for the entire study period, where vaccine efficacy was estimated to be 79% for antigenically matched A/H1N1 strains, 78.5% for all matched strains, and 71.5% for all strains, irrespective of antigenic match [ 1].
Similar(55)
In early November, the C.D.C. said that Haitian cholera samples matched strains commonly found in South Asia.
Tests confirmed that the samples matched strains of the disease found in those sickened.
Viral strains analyzed by direct PCR sequencing in original fluids completely matched strains detected after propagation in cell culture.
The average distance between matched strains was set at s = 300 variants.
On the other hand, data from community-based trials in years when poorly matched strains of influenza circulated in the community can provide insight into how well influenza vaccines protect against poorly matched strains.
This proved successful in that the majority of SSH sequences no longer matched strains RM1221 or 81 176.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com