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Recently, we have shown that castration results in massive inflammatory infiltration in the tumor remnant, and that infiltrating B cells promote tumor growth by lymphotoxin production that results in IKK α nuclear translocation and activation that in turn promotes tumor growth with a NF-κB-independent mechanism.
Tumors with a massive inflammatory infiltration are described in several organs.
Histological examination showed a moderately differentiated (G2) acinar adenocarcinoma associated with a stromal desmoplastic reaction and a massive inflammatory infiltration, made up mostly of CD3+ lymphocytes.
Because of histological, biological and clinical peculiarity, we propose to take into account pulmonary adenocarcinomas with massive inflammatory infiltration for a separate pathological classification.
Tumors with a massive inflammatory infiltration are found in different sites such as gastrointestinal tract, liver, breast and female genital system [ 1- 6].
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Intriguingly, the histopathologic examination revealed that Emuc expression by the ADV-Emuc-TVA transduction resulted in massive inflammatory cell infiltration and notable tissue damage in the muscular tissues and connective tissues in the samples at both 48 and 72 hpi, while the infections of the control viruses by contrast only caused slight confined inflammation (Figs. 1H and S3).
The histopathological hallmarks of H. pylori-induced disease are a massive inflammatory cell infiltration of the lamina propria and erosion of the gastric epithelium.
Histologic examination of the joints revealed severe articular cartilage erosion, bone erosion, massive inflammatory cell infiltration, and obvious pannus formation in the control group.
By contrast, even under GF conditions, AID−/− mice developed TLOs at 5 months of age, and subsequently gastritis lesions with epithelial hyperplasia and massive inflammatory cell infiltration at 12 months (Figure 6A).
The observed reduced susceptibility was restored by reconstitution of mast cells, highlighting the crucial role of these cells in promoting massive inflammatory cells infiltration [ 44].
Histological evaluation of the paws in the vehicle-treated arthritic animals revealed signs of severe arthritis with massive inflammatory cell infiltration, hyperplasia of the synovia, pannus formation, and bone and cartilage damage.
Related(17)
extensive inflammatory infiltration
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massive lymphocyte infiltration
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massive subcorneal infiltration
massive lung infiltration
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massive tumour infiltration
massive macrophage infiltration
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massive leukocyte infiltration
massive inflammatory vascularisation
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massive cell infiltration
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