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Whether PARP-1 activation in females is a consequence of massive inflammatory stimulus and whether females have evolutionarily developed pathways of inducing necrosis independently of PARP-1 remains to be determined.
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Low tidal volume ventilation with PEEP titrated to the minimal static elastance of the respiratory system could alleviate the inflammatory stimulus of massive brain damage.
Smale, S.T. Selective transcription in response to an inflammatory stimulus.
Cardiac CD11b/c cells arise as a potential source of this protective inflammatory stimulus.
These differences may be due to the origin of the inflammatory stimulus, i.e. LPS induced 'injury' versus the physiological inflammatory response of endometrial shedding (i.e. menstruation).
Of those, tens of millions are major ones that trigger massive inflammatory reactions in patients' bodies.
Whether all NSAIDs inhibit NF-κB activation induced by TNF, a most potent inflammatory stimulus, was investigated.
Secondary injury is mainly caused by metabolism disturbance, massive inflammatory response and neurotoxins that enlarge neuronal cell death1,2,3.
"Whereas, if you were going to implant them, they would induce a massive inflammatory response.
Moreover, preexposure to chorioamnionitis alters inflammatory reaction on a second inflammatory stimulus [15].
Sepsis is characterised by massive inflammatory response, which can affect vascular function.
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