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In this paper, a measurement criterion is presented to ensure the accuracy of mass detection using suspended microchannel resonators.

The principle of mass detection using carbon nanotube (CNT) resonators is based on the detection of the resonant frequency shift due to an attached mass.

To the best of our knowledge, despite recent studies [28, 29] theoretically reporting the nonlinear vibration of a graphene resonator, the nonlinear oscillation of a graphene resonator (particularly, nonlinearity tuning), as well as atomic mass detection using graphene-based nonlinear oscillators, has not been well studied based on a continuum elastic model and/or MD simulation.

Recently, Dai et al. [9] studied the nanomechanical mass detection using nonlinear oscillators based on continuum elastic model and obtained that nonlinear oscillation leads to the unique resonant frequency shift due to mass adsorption, quite different from that in harmonic oscillation.

Laboratory analyses of PCBs and chlorinated pesticides were performed by the Centre of Toxicology of Québec by gas chromatography coupled with mass detection using a chromatograph (model 6890) and mass detector (model 5973) from Agilent (Mississauga, Canada).

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Mass detection used a Quattro Ultima (Waters) in positive ion, multiple reaction monitoring (MRM) mode.

Figure 4 illustrates the power of the high-resolution/accurate mass detection used for this methodology.

The peak clusters were completed by a second mass peak detection using a signal-to-noise ratio of 2, valley depth of 2 and cluster mass window of 1 peak width.

Chemical composition of fractions was determined by rapid resolution liquid chromatography with mass selective detection, using Agilent Technologies 1200 Series liquid chromatograph coupled with Agilent Technologies 6410B Series triple-quad (QQQ) mass spectrometer.

The primer extended products were analyzed and the genotypes determined by mass spectrometric detection using the MassARRAY Compact system (Sequenom).

Matrix effects are a potentially significant problem in tandem mass spectrometric detection using direct injection with minimal sample preparation.

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