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The MYB expression pattern is reminiscent of markers of differentiating cell types such as Clara cells and MCCs, which are interspersed in the bronchial epithelium.
HB9/MNR2 and Islet1/2, markers of differentiating motorneurons, were also ectopically expressed in dorsally extended domains in hitchhiker mutants (Fig. 5K N).
RNA-seq from mex3-1 RNAi) animals confirmed that mex3-1 is a master regulator of genes expressed in post-mitotic neoblast progeny and also identified novel markers of differentiating cells in planarians.
DsRed (middle panel) did not colocalise with GFP in Sod1-G93Ros10-Sh1 transgenicrossedfish crossed with hb9-GFP (row1), islet-1-GFP (row 2) (markers of differentiating motor neurons) and did not immunolabel with ChAT antibody (row 3)(marker of mature motor neurons).
This is also suggested by the presence of markers of differentiating muscle, such as skeletal muscle myosin or troponin, expressed at this stage in the myotome of the somite.
Similar(55)
Given these results, we did not expect that GS cells on laminin would strongly upregulate Kit, a marker of differentiating spermatogonia.
The appearance of A1 coincides with the expression of the Kit receptor, a marker of differentiating spermatogonia that is expressed until the preleptotene stage and then is down-regulated at the time of meiotic entry [5] [7].
cKIT is a marker of differentiating spermatogonia in rodents and, as expected, was essentially absent in juvenile rhesus testes, which contain only undifferentiated Adark and Apale (Fig. 4G I).
Having identified E-cadherin as a marker capable of differentiating cellular subsets, we repeated flow cytometry analyses with E-cadherin (Figure S3).
Serial serum PCT seems to be a marker capable of differentiating chronic critically ill patients with manifested infections compared to those presenting with fever of non-infectious origin, demonstrating both diagnostic and prognostic value.
In colorectal tumorigenesis, APC has never been proposed as a useful prognostic or predictive marker capable of differentiating between patients; thus, changes in APC status currently have no role in clinical practice.
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