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The low density of molecular markers has limited the efficiency and accuracy of QTL mapping.
However, the anonymous nature of these dominant markers has limited the transfer of linkage information between studies [ 16, 23].
However, the relatively low production and the introduction of antibiotic resistance markers has limited the application of these recombinant strains for commercial scale (Table 2).
The low number of polymorphic RFLP markers has limited the development of dense genetic maps in wheat and the number of available anchor points in comparative maps.
While these have delivered their immediate aims, the lack of a comprehensive common set of reference markers has limited the number of opportunities to align these maps and, so, the associated trait data produced for different studies.
Even if s-HER-2, like other circulating tumor markers, has limited usefulness for diagnosis and/or screening of BC, the US Food and Drug Administration FDAA) introduced its serum levels measurement for monitoring trastuzumab treatment in BC patients with HER-2 positive tissue and serum expression [ 50].
Similar(54)
Moreover, those markers have limited application in the identification of novel alleles at the Pi2/9 locus.
Still, these markers have limited availability and thus cannot be advocated for routine guidance of therapy.
Serum markers have limited value in follow-up since disease progression has been shown in the presence of normal serum marker levels [17].
As a result, leaked markers have limited sensitivity and specificity.
However, clinical studies have produced conflicting results, and reliable markers have limited availability.
Related(20)
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