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The demand for earlier markers has prompted the discovery of several candidates to serve this purpose.
The increasing availability of high-throughput genetic markers has prompted the development of new methodologies for identifying and targeting the molecular basis of complex phenotypes in breeding programs.
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Despite a reasonably useful sensitivity and specificity profile, the fact that prenatal screening tests are typically usable at a relatively narrow gestational window and the need to combine multiple markers have prompted workers to explore new approaches for noninvasive prenatal diagnosis.
An increased availability of genotypes at marker loci has prompted the development of models that include the effect of individual genes.
The heterogeneity of diffuse large B-cell lymphoma (DLBCL) has prompted the search for new markers that can accurately separate prognostic risk groups.
A growing understanding of the pathophysiology of aneurysmal SAH has prompted efforts to identify serum markers that can predict outcomes in these patients.
Likewise, the emergence of high-throughput genotyping technologies and genome-wide association studies has prompted the search for genetic markers of diabetes predisposition or susceptibility.
14 Although clinicians are now better able to prevent and manage the side effects associated with IL-2, its toxicity has prompted a search for predictive markers to determine which patients would benefit from this therapy.
The development of experimental expertise recommender systems has prompted innovative research into the use of expertise markers found on routine information artifacts.
In section Methods, we first introduce an example of a simple interplay between two markers (effect modification) that leads to marginal crossing hazard functions and has prompted us to derive a novel pseudo-R2 measure for such non-proportional situations.
This has prompted a number of groups to examine potential endogenous markers of hypoxia, which include proteins that are upregulated under hypoxia.
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