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Serial quantitative echocardiographic analysis, as compared with traditional clinical markers, can result in better timing of surgical intervention for aortic regurgitation.
Derangement in fibrinolytic markers can result in thrombosis and cardiovascular problems.
Therefore, combining the posterior probabilities of closely located markers can result in higher power when inferring the presence of a QTL [ 23].
However, the effects of natural selection on these markers can result in homoplasy that has the potential to mislead phylogenetic analyses [ 6].
The selection based on these DArT markers can result in selection of SHWs carrying better grain size and shape phenotypes which can be exploited for wheat genetic improvement.
Because non-independence of linked markers can result in highly conservative significance thresholds [ 42], we set a threshold -log(P) value of 3.6 (alP=0.00025 P=0.00025, log 1/ P=3.60) to identify significant associations using a multiple testing correction method that accounts for correlation among markers while also controlling the type I error rate [ 43].
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Although this current study identified the prognostic importance of C1M assessment in serum, it remains to be shown whether lowering this marker can result in a reduction of the mortality risk.
In addition, the use of ferritin as a marker can result in non-representative values for iron deficiency in the setting of chronic inflammation; however we have used, along with ferritin, sTfR for defining iron deficiency, which reflects the degree of tissue iron supply as well as iron stores [ 45].
However, use of adjacent marker information can result in over- or under-smoothing, undesirable window boundary specifications, or highly correlated test statistics.
Our previous studies on serotonin function (Beyer et al., 2012) and the role of ATP4 in LR development (Walentek et al., 2012) have revealed that aberrant LR marker gene expression can result from defects in the specification of the SM, from reduced cilia length or mispolarization, or from loss of cilia altogether, all of which result in altered flow patterns.
The uncertainty introduced by ordering co-located markers can also result in somewhat larger linkage groups.
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