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Exact(5)

The non-recombining nature of this chromosome region as well as the availability of a reliable molecular clock, through the established mutation rate of STRs, allows a chronological reconstruction of haplotype genealogy, when these different types of markers are analysed jointly [14] [17].

This is unrealistic to accomplish when thousands of genotyped markers are analysed simultaneously.

A more crucial issue is the way in which continuous markers are analysed.

Ex-linked markers are analysed by fitting an additive effects-only logit model which equates the risks of male hemizygotes with female homozygotes.

Until now, these various genetic markers are analysed separately by conventional karyotyping, 24-colour karyotyping, FISH and/or LOH studies (Ambros et al, 2003), making these analyses time consuming and rendering their interpretation difficult as not all markers could be studied at one time.

Similar(55)

When the concentration of inflammatory markers was analysed, a decline in all the analysed parameters except TNF was observed.

To confirm this hypothesis, the coexpression of Delta1 with distinct cell cycle markers was analysed in the caudal spinal cord.

To explore the consequences of Hex-AVE ablation, the expression of primitive streak markers were analysed in Hexdact/+ embryos.

To further characterise the extent to which the AVE is affected in Hexdact/+ mutants, the expression of five AVE markers was analysed at 6.5dpc.

The presence of both SEPT9 and ALX4 markers was analysed in cohort II and was observed in 5% of controls (1/22) and 37% of patients with polyps (18/49).

The activation of cardiac-specific markers were analysed by: immunohistochemistry with bright field and immunofluorescent microscopy, electron microscopy, PCR and RT-PCR.

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