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The WMHs may be an indirect marker of focal cerebral hypoperfusion induced by migraine attacks.
When cells were grown on fibronectin, staining of paxillin, a marker of focal adhesions, demonstrated that paxillin-positive adhesions were present within control and Crk knockdown cells.
According to Korzeniecka-Kozerska et al. (2013) [ 120], matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin (MMP-9/NGAL) is a better marker of focal glomerulosclerosis.
The presence of stress fibres and phosphorylated FAK is a marker of focal adhesions that anchor the F-actin filaments to transmembrane proteins and mediate communication with the cell's environment suggesting that PHD3 as oxygen sensor also influences tumour cell invasion and possibly cell migration with the biological function of escaping hypoxic areas.
We hypothesized that matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin (MMP-9/NGAL) is a better marker of focal sclerosis in the glomerulus then matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) and matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 metalloproteinase-2
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It is widely used as a marker of 'classic' focal adhesions, which are usually located at the cell periphery, are highly tyrosine phosphorylated, and contain αvβ3 integrins.
To gain additional mechanistic insight into these changes, we immunostained drug-treated U373 MG cells for vinculin, a marker of mature focal adhesions, and NMMII, the molecular motor whose activity underlies stress fiber contractility (Fig. 4a).
As a marker for focal adhesions we used GFP-tagged vinculin, a cytoskeletal protein.
Arrows mark sites of focal Mic60.
In relapsing onset phenotype, the independency between Phase 1 and Phase 2 suggested a two-stage disease, with a first stage during which focal inflammatory lesions influence disability progression and a second stage during which disability progression is independent of focal inflammatory markers.
Glomeruloid microvascular proliferations (GMP), a novel angiogenesis marker, are focal aggregates of small vessels resembling a renal glomerulus (Pettersson et al, 2000; Sundberg et al, 2001).
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