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Yawning, used as a marker of central cholinergic activation, was also monitored.
Several lines of evidence suggest that the auditory evoked potential (AEP) augmenting/reducing slope may serve as a biological marker of central serotonergic activity.
Processing speed, which can be measured behaviorally in various sensory domains, has been shown to be a strong marker of central nervous system health and functioning in adults.
It has previously been suggested that auditory event related potentials (AEPs) are a potential marker of central serotonergic (5-HT) activity in man, with the slope of the AEP amplitude stimulus intensity function (ASF-slope) inversely correlating with 5-HT activity.
Animal studies [31] have also shown that depression may induce hyperalgesia, another marker of central sensitization.
As a marker of central sensitization, allodynia has been proposed as a risk factor for progression to chronic migraine [6].
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These findings indicate that markers of central fat distribution which are widely known to reflect visceral fat content can not be underestimated when evaluating cognitive functioning in older persons with DM, especially for global, executive and attention functioning.
We also examined markers of central adiposity.
We also noted significant overlap with markers of central nervous system cell types (neurons, oligodendrocytes and astrocytes).
Waist circumference, waist-to-height ratio, and subscapular to tricipital skinfold were used as surrogate markers of central body fat.
Anthropometric measures include markers of general adiposity, such as weight and body mass index (BMI) and markers of central adiposity, such as hip or waist circumference.
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