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Exact(6)
Such studies make a strong circumstantial case for lactate as a marker of dysoxia.
However, tissue hypercapnia is not just a marker of dysoxia but is also an indicator of hypoperfusion.
However, Schlichtig and Bowles [ 7] showed evidence supporting the role of intramu-cosal P CO2 as a marker of dysoxia in extreme hypoperfusion, when V O2 falls.
A great body of literature supports the role of intestinal P CO2 as an early marker of dysoxia and regional hypoperfusion.
In fact, a high gastric arterial PCO2 gradient could be a marker of dysoxia, irrespective of the causes of impaired oxygen utilization, although blood flow is always the major determinant of this gradient.
All together, the four studies [ 1, 2, 3, 4] demonstrate the following: that ΔP CO2 cannot be taken as a surrogate marker of dysoxia; and that increased ΔP CO2 cannot occur when flow is constant.
Similar(54)
In this setting, it appears reasonable to use lactate production as a single marker of organ dysoxia predictive for operative mortality.
The role of ScvO2 as a reliable marker of global dysoxia has been widely accepted [ 1, 2].
These latter findings suggest that the PslCO2 PaCO2 gradient may be a better marker of tissue dysoxia than are these other parameters.
With respect to the lower hemoglobin levels and the severity of circulatory dysfunctions in transfused patients, it is likely that physicians followed a common pragmatic decision-making process at the bedside, based not only on a sole hemoglobin level but also on markers of tissue dysoxia.
Normally, outer medullary cells live on the edge of dysoxia.
Related(20)
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