This dose induced robust pulmonary neutrophilia, production of inflammatory cytokines, and elevated serum markers of distant organ injury.
Additionally, 11q13 gains were correlated with poor prognosis of patients with other tumors, such as prostate (38) and thyroid (39), larger tumor size in hepatocellular carcinoma (40), and were suggested as predictive markers of distant recurrence in patients with breast cancer (41).
Moreover, RbAp46 overexpression correlates with migration of lung cancer cells and serves as a prognostic marker for distant metastasis of non-small cell lung cancer [ 20].
The Thorazine, imipramine, benzodiazepines, opiates and rivers of alcohol, the serotonin reuptake inhibitors, the uppers and downers, inners, outers, laughers and screamers, are all markers of a distant past.
Methylation of the CDO1 promoter was recently shown to be a strong marker for distant metastasis in lymph node positive, estrogen receptor positive breast cancer patients.
Similarly, both Guntupally et al (2012) and Simpkins et al (2013) demonstrate that LVSI is highly associated with LN metastasis and is a strong marker of local and distant disease recurrence.
In summary, our data underline the importance of stemness-associated markers for the prediction of distant spread and the prognostification of CC.
