Sentence examples for marker linkage tests from inspiring English sources

Thus, approximately 103 true-positive trans-acting QTL are detected in the 5067 random single marker linkage tests.

There were 157 linkages called significant at LOD≥1.37 among the 5067 random marker linkage tests, and the associated FDR was ≈0.342.

First, we estimated the proportion of truly null tests (denoted π0) and truly alternative tests (1−π0) across all 5067 single marker linkage tests performed at the marker closest to the locus of the gene in question.

The estimate of π0 for this set of tests is approximately 0.898, indicating that about 518/5067 of these single marker linkage tests at random loci detect true trans-acting QTL.

Assuming that trans-acting regulatory QTL are distributed randomly with respect to their target genes, we estimated the rate at which these single marker linkage tests detect linked trans-acting regulatory QTL by testing each gene expression trait for linkage to randomly chosen markers in the genome [23].

Effect sizes for the SNPs analysed using single-marker linkage test were nearly 2-fold higher than effects identified using multi-SNP models (average R = 3.8%).

We searched for QTL linked to these metaphenotypes by applying a non-parametric linkage test at every marker position, as previously described [ 58].

For analysis of sporadic RCC patients and controls, deviation from Hardy Weinberg proportions for the genotypes of both markers and linkage disequilibrium between marker alleles was tested by χ2 tests.

Pedigree-based linkage methods [e.g. 16], [17], [18], [19] and some population-based methods [e.g. 20], [21] use the knowledge of relationships and transmission of alleles among family members combined with marker-phenotype tests to infer linkage and/or association.

A single-marker test for linkage between marker and QTL considers marker allele frequency differences between high and low groups.

We then genotyped the Mus Chr 10 marker Plagl1 to test for linkage to the Mus Ch17 markers and found Mas1 to be linked at a distance of 21.2 cM (LO D= 7.1).