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Thus, our mass spectrometry data show that serum Hep-1 represents an convenient marker in mouse models of inflammation and iron overload.
CD34 is a well-established haematopoietic stem cell marker and was proposed as stem cell/progenitor marker in mouse oesophagus.
β1-integrin has been characterised in human skin, 16 CD34 has been proposed as an epithelial stem cell marker in mouse oesophagus 8 and melanoma chondroitin sulfate proteoglycans (MCSP) has been identified as a potential marker for cells expressing high levels of β1-integrin.
However, our results, showing that anti-NPM antibodies are constantly detected in WB mice and frequently observed in patients with SLE, demonstrate that anti-NPM antibodies constitute a frequent and new marker in mouse and human lupus, establish a clear relationship between anti-NPM and aCL antibodies and finally define a subset of patients with aCL antibodies.
Of note, neither Arginase 1 (Arg1), which is largely used as a M2 marker in mouse but not in human (Chinetti-Gbaguidi and Staels, 2011; Pourcet and Pineda-Torra, 2013), nor il10 (data not shown), a known M2 marker in mammals (Mantovani et al., 2002), was detected in zebrafish macrophages.
No significant decrease was observed in body weight or residual amount of [H]dextran, which is an impermeable marker, in mouse brain up to 72 h after the administration (data not shown), suggesting that a single dose of 1,25(OH)2diddid not cause significant toxicity or disruption of BBB integrity.
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More recently, the zinc-finger protein Zfp423 was identified as a preadipocyte marker in mice, produced by cells that reside in the adipose vasculature (Gupta et al., 2012).
CD73 has been described as a retinal photoreceptor progenitor marker in mice [ 36– 38] and found on human RPE cells as well [ 39].
Therefore, this reporter is a lineage marker: in mice carrying both the Foxb1 Cre and the ROSA26R alleles, cells expressing Foxb1 and any cell derived from them will permanently express β-galactosidase.
A 0.567 kb fragment from exon 1 of Gpr120 was replaced by a nuclear LacZ expression cassette (in frame) alongside a LoxP floxed PGK-neo selection marker in mice from a pure C57bl/6 genetic background in a colony maintained by AstraZeneca (M. Bjursell, unpublished observations).
Of particular note, K6 is regarded as a putative multipotent/bipotent mammary epithelial progenitor cell marker in mice due to its strong expression in the body cells of TEB, its transient expansion during early pregnancy, and its persistent although rare expression during pregnancy, lactation, and involution (Grimm et al. 2006; Sapino et al. 1993; Smith et al. 1990).
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Justyna Jupowicz-Kozak
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