The aim of the present study is to measure the blood concentration of multiple blood markers in stroke patients and investigate the clinically available blood markers for prediction of the long-term clinical outcome.
Our finding of the strong association between IL-6 and poor stroke outcome is consistent with those of several studies using multiple blood markers in prospective stroke cohorts [ 4, 5].
Consistently, we show that activated pericytes express microglial markers in human stroke brain tissue.
Interleukin-6 (IL-6) interleukin-1 beta (IL-1b), and tumor necrosis factor-alpha (TNF- α) are one of the important atherogenic markers in ischemic stroke patients.
Although serum lipid levels have not been shown to act as a surrogate marker for stroke, in landmark lipid-lowering trials, statin therapy has been associated with reductions in the incidence of ischemic stroke in patient populations with manifest ischemic heart disease.
The discovery and replication studies presented here also show IGFBP4 to be a risk marker for stroke in postmenopausal women, which appears to be a novel finding.
This parameter could be a novel marker of stroke in addition with other cytokines (IL-6 and IL-8) [ 14], even if the cytokine upregulation follows as a fall mechanism not sufficiently regulated, which worse often the clinical course of neurological event.
Imagine the Life You'd Love to Live, Then Live It... that book has lots of WTF phrases in thick black magic marker strokes in the margins, penned by me with a vengeance.
2013 44:2064–2089; 3. Katan M, Fluri F, Morgenthaler NG; et al. (2009): Copeptin: a novel independent prognostic marker in patients with ischemic stroke.
