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Exact(7)
Therefore, increasing marker density does not necessarily clarify the QTL region boundaries when using LM analysis.
Conversely with LD spanning a longer distance, the resolution will be poor, but the marker density does not need to be high.
Simulations that vary marker spacing show that although high marker density does not improve the power to detect loci, it has a significant effect on the precision of QTL localization (Darvasi et al. 1993; Stange et al. 2013).
While the high marker density does not immediately help to narrow QTL regions because of the lack of recombination events in the F2 design, it does help to increase the precision of the line origin estimation.
The fact that precision doesn't increase with the decrease of marker spacing for both BGF and LSR analysis shows that without enough information, higher marker density does not necessarily result in higher precision for mapping.
If the marker density does not take into account the LD structure in the study population, we suggest cleaning the data from markers in LD blocks before running Haplous.
Similar(53)
We also found that the size of training population had a greater impact on predicting hybrid performance than the marker density did, which was in accordance with earlier studies.
Moreover, increasing marker density did not result in a higher BF.
In contrast, marker density did not have a significant effect on detectability of QTL at the range of 0.2−20 markers per cM.
This study also showed that the seeding density does not affect cellular properties of MSCs including cell surface marker expression.
Sampling density does not seem to influence the phylogenies obtained from the chloroplast markers as much as it affects the nuclear trees.
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