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Interestingly, accumulation of Nhtt138Q markedly increased accumulation of the aggregated form of gp78, which was accompanied by a time-dependent decrease of monomeric gp78 and an increase in induction of ER stress as monitored by CHOP and BiP expression (Fig. 1B).

In the blue-green alga Synechocystis sp. PCC6803, overexpression of endogenous and exogenous genes encoding PUFA desaturases markedly increased accumulation of ALA and SDA and decreased accumulation of linoleic acid and γ-linolenic acid.

While the nec1 mutant showed markedly increased accumulation of H2O2 compared to wt NEC1 plants, the experiment did not reveal a significant effect of mlo-5 mutation on H2O2 over-accumulation in nec1.

Flow cytometry analysis showed that αB-crystallin knockdown resulted in a markedly increased accumulation of annexin V-positive RPE-MC cells, indicating that αB-crystallin knockdown caused the autophagy inhibition-induced death of RPE-MC cells to change direction from a nonapoptotic cell death to an apoptotic cell death.

Likewise, PANC-1 tumors also showed a markedly increased accumulation of long-circulating AuNP3s with the target-to-background ratio ranging between 2 and 4. We evaluated the use of AuNP3s as a potential vector for applications in noninvasive RF cancer therapy.

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Studies performed by ACTX-6, an L-amino acid oxidase from A. acutus showed flow cytometry analysis it could markedly increase accumulation of sub-G1 phase, which suggested induce apoptosis [ 32].

By overexpression of endogenous and exogenous genes encoding PUFA desaturases, we markedly increased the accumulation of ALA and SDA and decreased the accumulation of LA and GLA in this cyanobacterium.

In present study, pretreatment with hydrogen sulfide donor sodium hydrosulfide (NaHS) markedly increased the accumulation of endogenous H2S in maize seedlings under normal culture conditions, which in turn improved survival percentage of maize seedlings and mitigated increase in electrolyte leakage and malonaldehyde (MDA) accumulation under heat stress.

It was shown that drought stress markedly increased ABA accumulation in rice grains and substantially decreased grain GA content [ 42].

In both HEY and IOSE80ht cells, Rab25 expression markedly increased the accumulation of glycogen in cells released from starvation (p < 0.01).

Altogether, our data suggest that extracellular calcium, probably through its binding to ibandronate, markedly increased its cellular accumulation and its inhibitory activity on breast tumour cells.

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