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In this study we show that peripheral chemoafferent activity in normoxia and in conditions of hypoxia is markedly enhanced during early systemic exposure to inflammatory stimuli.

In sheep, the expression of Kiss1 mRNA in the arcuate nucleus is markedly enhanced during the pre-ovulatory LH surge (Smith et al., 2008b).

In the primate model of HIV infection, i.e. simian immunodeficiency virus (SIV) infection, vaginal transmission of SIV was markedly enhanced during the use of progesterone-releasing implants (Marx et al., 1996).

Expression of a number of pro-inflammatory genes, including iNOS, was markedly enhanced during cytokine exposure and was in most cases significantly down-regulated in presence of SJW extract or HPF, in both rat and human islets.

Some evidence indicates that mobilization of lead from bone may be markedly enhanced during the increased bone turnover of pregnancy and lactation, resulting in lead exposure to the fetus and the breast-fed infant.

Similar(55)

Therefore, these oxidant-antioxidant imbalances (oxidative stress) may represent a pathogenic loop that results in markedly enhanced oxidative stress during TB infection [ 97, 98].

For example, the transcriptional rate of the IL-6 gene is markedly enhanced and IL-6 mRNA upregulated during muscle contraction [ 83].

Furthermore, in males treated with mite allergen, maternal exposure to 100 μg DEHP during neonatal periods markedly enhanced the protein expression of eotaxin compared with vehicle exposure (p < 0.05).

In agreement with this homeostatic role, liver G6Pase catalytic function is downregulated by insulin response to feeding [12] while it is markedly enhanced by the high glucagon levels occurring during fasting periods [13].

In contrast, fast reapplication of Cu-Phen during depolarization to +30 mV markedly enhanced the current (Figure 6D, red trace after the arrow), a feature which was reversed following exposure to 1 mM DTT.

We showed in the present study that survivin was markedly enhanced in GSC compared with their differentiated counterparts, and that its expression was potentiated during the dedifferentiation process in a similar way to the stem markers.

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