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The nucleus of epidermal keratinocytes (KCs) is a complex and highly compartmentalized organelle, whose structure is markedly changed during terminal differentiation and transition of the genome from a transcriptionally active state seen in the basal and spinous epidermal cells to a fully inactive state in the keratinized cells of the cornified layer.
The scenario of land use had markedly changed during the years due to the canal irrigation.
The dose of concomitant medication was not markedly changed during this trial.
Otherwise, the dose of medication should not be markedly changed during two weeks prior entering into this study.
Interestingly, the filopodial dynamics at the front of the tip cells was not markedly changed during cell division, despite the mitotic rounding of the cell body (supplementary material Movie S1c).
Guidelines for nutrition behavior and lifestyle have markedly changed during the 20th century according to society and population changes that could have influenced the athletes weight management at the sport competition retirement [ 35].
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The quick response (1 2 h) of amoA mRNA transcription to the recovery of ammonia oxidation activity induced by the sudden exposure to ammonia was observed in a short-time batch-mode incubation whereas the amount of amoA DNA did not markedly change during the incubation under any conditions.
Water intake increased or decreased but did not markedly change during this period (Fig. 4b).
Thyroid hormone levels markedly change during childhood without showing significant sex differences, except for fT3.
APP like immunoreactivity was detectable in Western Blot as a single band at approximately 110 kDa (Fig. 2), but did not markedly change during aging.
3– 8 However, LTG pharmacokinetics markedly change during pregnancy 9– 18 and if a woman with epilepsy remains on her pre-pregnancy LTG dose, concentrations may decrease significantly and lead to an increase in seizure frequency for some women.
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