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Also the evaluation of the neuronal loss, both in striatum and in cortex, confirmed the marked protective effect of NC.
APO866 had a marked protective effect on CIA observed in 3 independent experiments, with a maximal therapeutic response when administered at 10 mg/kg (Fig. 2a).
Retroviral transduction of Bcl-xL into MCF-7 cells resulted in a pronounced protein overexpression (Fig. 5c) and had a marked protective effect on mitomycin C induced apoptosis (data not shown).
Furthermore, our results highlight the need for caution in interpreting observational data of vitamin D supplementation and cancer survival, given the marked protective effect on mortality seen in women with breast cancer who are prescribed supplements, compared with those never prescribed supplements.
It is noteworthy that the odds ratio confidence interval at Arg381Gln for UC (0.73 [95% CI, 0.55 0.96]) does not overlap with that for CD (0.38 [95% CI, 0.29 0.50]), suggesting a significantly less marked protective effect of the rare allele for UC compared with CD.
The study by Zar et al. demonstrated a marked protective effect in terms of prevention of TB (RR 0.28 (95% CI 0.1, 0.78) p = 0.005) and TB mortality (RR 0.46 (95% CI 0.22, 0.95) p = 0.015) among HIV-infected children and is therefore worth commenting on [ 18].
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13, 16, 19– 21 This result is in agreement with other studies confirming that SDF1-3′A homozygosisy is associated with a faster CD4 T cell decrease and a rapid progression to AIDS.8.22,26 However, different investigations confirm that, in contrast, SDF1 3′A/SDF1 3′A has a protective effect, and there was a marked slowing in progression to AIDS.
The protective effect was particularly pronounced at 45 °C (Fig. 8).
A marked departure of dj from zero indicates a deleterious (or protective) effect of allelic variant j on disease risk.
The protective effect of a late puberty was more marked for tumours of other histologies.
The protective effect of the rs1421085 C allele was more marked after adjustment for BMI in African-Americans.
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