Sentence examples for marked modulation of from inspiring English sources

Moreover, treatment of both cell lines before or after UV-B irradiation with 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D, and/or epigenetic modulating drugs (TSA; 5-Aza) did not result in a marked modulation of the protein expression of Notch-1 or Jagged-1.

These findings suggest that T. whipplei infection results in a marked modulation of apoptosis-related proteins.

Treatment with ibuprofen for 48 h at all concentrations downmodulated S-phase-critical genes, including E2F1 as well as the E2F1-regulated genes, and treatment for 72 h showed a marked modulation of apoptosis-related transcripts (Table 3).

Conversely, a marked modulation of the progression of neu carcinogenesis is evident in mice in which the gene encoding IFN-γ [ 26] or that encoding monocyte chemo-attractant protein (MCP -1/CCL2 [ 27] has been knocked out.

As for VEGF gene expression, iloprost infusion showed a strong effect on the transcriptional profiles of CECs isolated from patients with SSc both in the presence or absence of digital ulcers, since it induced a marked modulation of the differently expressed genes.

However, both agents induced marked modulations in the levels of Bcl-2– and Bax-positive cells when tested either individually or in a binary mixture.

DNA microarray studies using T. rubrum and synthetic inhibitors of FAS (PHS11A and PHS11B) have shown marked transcriptional modulation of several genes such as FAS1 and FAS2, ERG6 (a gene involved in ergosterol metabolism), and multidrug resistance genes [ 13, 14].

Multisymbol codes in which messages are first mapped into sequences of symbols (source coding) and then systematically mapped into message marks (modulation) reduce computational complexities.

Although clearly numerous PTMs affect PcG biology, molecular mechanisms in signaling to chromatin, downstream modulation of epigenetic marking and the establishment and transfer of heritable epigenetic states remain largely elusive.

The molecular pathways triggered in these cells induce marked changes in gene expression causing modulation of their cellular phenotypes resulting in proliferation, differentiation or migration.

One hundred-nanometer nanopore diameter was marked as the transition step in the modulation of cell viability by the nanoporous surfaces.