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We provide simple illustrations of the fact that complexity in rate independent athermal plastic flows is due to marginal stability of the underlying elastic system.
Finally, the pervasiveness of extraordinary stability in designed proteins challenges accepted models for the "marginal stability" of natural proteins, suggesting that there must be a selection pressure against highly stable proteins.
Despite their many favorable qualities, the marginal stability of biocatalysts in many types of reaction media often has prevented or delayed their implementation for industrial-scale synthesis of fine chemicals and pharmaceuticals.
The present findings provide a unique perspective to look at "marginal stability" of proteins (ΔG folding ∼ 10 kcal/mol) that are reported in numerous studies from present and past [79] [81].
This marginal stability of natural proteins has been noted previously, and been given two distinct explanations.
Similar(55)
While the requirement of marginal stability to ensure protein functionality was an established finding, mechanism through which hydrophobicity content of a protein can be related to its marginal stability was not exactly clear.
This linear combination of standard fluxes stabilizes the updates such that the time-step yielding marginal stability for arbitrarily small cut-cells is of the same order as that for regular cells.
Importantly, it reproduces many known properties of proteins and their evolution, such as the observed marginal stability, the higher rate of evolution of exposed locations compared with buried locations, the tendency for hydrophobic residues to cluster in the interior, the dependence of protein stability on population size, and over-dispersion of the molecular clock (Goldstein 2011).
In the current analysis of marginal stability, the kinetic effect played an important role.
The lines of marginal stability are determined by solving the equation λ 1 = ± 1 and λ 1 λ 2 = 1.
Thus, it is inferred that the dendrite fixes its tip radius because of marginal stability considerations, but the coarsening driven solute flow modifies the concentration gradient experienced by the dendrite envelope thereby influencing the location of the first secondary instability.
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