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The modest stability of the wild type prevents a critical analysis of these interactions because even moderately destabilizing mutations lead to a very small folded state population.
Interestingly, the importance of the S17,T21 sites is validated by the higher, albeit modest, stability of the S17,T21A-BMAL1 mutated protein as compared to the wild type BMAL1 (Fig. 3E,F).
The high degree of variability seen in the length of S0 from channel to channel and structure to structure most likely reflects the modest stability of this helix.
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This indicates a systematic deviation of ωML from ωpop in the regime of modest stability.
This is in line with previous studies that showed that response time variability in children and adolescents was of modest stability [ 81] and that response inhibition is stable in test retest [ 85].
Increase sales with modest stability during the second year of operation.
Modest stability in ADHD symptoms from 54 months to third grade was found.
Surprisingly, frGFP displayed a modest stability during equilibrium unfolding suggesting that the evolved variants were not isolated based on surpassing a threshold of equilibrium unfolding stability.
This modest stability is thought to be critical for protein function, which usually requires a certain degree of structural flexibility and involves conformational changes.
The modest genetic stability of these traits during childhood implies, however, that the underlying genetic architecture is likely to be complex and variable during development.
Differential scanning calorimetry experiments revealed that the mutation caused a modest increase in thermodynamic stability of the Fab, a feature predicted by the computational model.
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