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Quantitative trait loci (QTLs) modulating lung tumor size have been mapped in mouse models [ 1, 2].
In parallel with human studies, malaria susceptibility genes have been mapped in mouse models, and the role of some genes has been demonstrated [ 2].
The Rtm1 locus is novel and unique, as no other loci modulating renal tumorigenesis have previously been mapped in mouse crosses.
86 Genetic modifiers have been mapped in mouse models of recessive PKD, and in one case, the Kif12 gene was identified as a possible modifier in the cpk mouse.
As an additional validation of the technique, we performed ChIP-seq to identify CCAAT/enhancer-binding protein α (Cebpα) transcription factor binding sites, because this protein has an integral role in hepatic energy metabolism [ 24], and its binding pattern has been previously mapped in mouse livers [ 25], allowing for a direct comparison.
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Susceptibility loci for a variety of cancers have been mapped in mice, including a Cdkn2a allele in lymphoid malignancies and a Ptch allele in skin cancer.
An alcohol preference locus has been mapped in mice to the region where 5-HT1B is located [ 37]. 5-HT1B receptor knockout mice were found to have increased aggressive behavior [ 38] and increased spontaneous alcohol consumption [ 39].
Two HLA-A2- and HLA-24-restricted CD8 T-cell epitopes of GPC3 have been mapped in mice and shown to elicit T-cell responses in HCC patients after long-term in vitro stimulation of PBMCs [ 34].
The sequences were mapped in the mouse genome from EnsEMBL mouse genome database [ 51].
Seven recombination-associated loci have been mapped in the mouse genome, and the genetic locus with the highest LOD score in mouse maps close to Tex11 on the X chromosome (Murdoch et al, 2010).
Significant characteristics of the KIF27 genes mapped in human, mouse and rat included a conserved 18 exon arrangement and the existence of at least three mRNAs that resulted from alternative splicing, at least in human.
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