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This study reports the highest resolution map of copy number variation in the cattle genome, with 304 CNV regions (CNVRs) being identified among the genomes of 20 bovine samples from 4 dairy and beef breeds.
Our results provide a significant replenishment for the high resolution map of copy number variation in the bovine genome and valuable information for investigation of genomic structural variation underlying traits of interest in cattle.
With an average probe spacing of 420 bp relative to the latest bovine genome assembly (BT4, 2007) [ 2], this analysis provides the highest-resolution map of copy number variation in the cattle genome to date.
This analysis provided a high-resolution map of copy number variations in the pig genome with a median probe spacing of 2506 bp relative to the latest porcine genome assembly (Sscrofa9.2).
Our study firstly provides a comprehensive map of copy number variation in the pig genome, which would be of help for understanding the pig genome and provide preliminary foundation for investigating the association between various phenotypes and CNVs.
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In this study we provide a cross-population, microarray-based map of copy-number variant regions (CNVRs) to enable reliable interpretation of CNV association findings.
Here we provide a cross-population, microarray-based map of copy-number variant regions (CNVRs) to enable reliable interpretation of CNV association findings.
For chromosome 8, a fine-mapping of copy number alterations revealed gain of DNA between the chromosomal localizations 90.32 Mb and 146.27 Mb with a small disruption between 137.06 Mb 139.4 Mb (Figure 2B).
SNP arrays therefore provide the potential for fine mapping of copy number changes, enabling the identification of small aberrations and accurate mapping of chromosomal breakpoints.
This notion changed in 2004 when two groups of researchers published the first genome-wide maps of copy number variation in seemingly healthy individuals [ 6, 7].
A 32 k aCGH platform was used for high resolution mapping of copy number changes in 30 stage I-IV ESCC.
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