Sentence examples for many residues within from inspiring English sources

The benzyl ring featured in many antifolate inhibitors forms hydrophobic contacts with many residues within the DHFR active site [46, 51].

Both VirB8 proteins are similar in size and composition to other VirB8 and VirB8-like proteins, with many residues within superimposed α-helices and β-strands of the solved crystal structures [94], [95] conserved in both proteins (Figure 4A).

The functional significance of the G-loop in Kir6.2 is demonstrated by the fact that many residues within this loop are mutated in human disease.

As presented above, histones are modified at many residues within the tails or even the globular domains, where different covalent modifications can be found [ 10, 25].

Many residues within the kinase domain are conserved between eEF2K sequences from disparate species and between these enzymes and other members of the α-kinase family [ 34].

Importantly, many residues within the hydrophobic core are associated with drug resistance, and mutations in the core likely affect the dynamic properties of HIV PR and potentially affect the ability of PR to bind inhibitors and substrates.

These residues are marked in Figure 2. From the multiple sequence alignment it can be concluded that many residues that bind to NADP are highly conserved within the family (9 out of 22).

The SRS4 (i.e. the I-helix) has many residues important for influencing the orientation of the substrate within the active site and for the transfer of the oxygen during product formation via a negatively charged residue (Asp/Glu) together with a polar uncharged side-chain (Ser/Thr) residue.

Figure 5, panels B and D, highlight the CICPs that appear primarily within the interior of the protein where many residues show contact with distant residues.

In contrast, many residues that are mutated in nonresponsive forms of α-Gal A were located within, or in close proximity to, the active site (Fig. 4B).

Fusion of Ngb to the TAT sequence might block the binding of Ngb to Gαi and/or induce changes in the Ngb−Gαi interaction, due to the presence of many positively-charged residues within the TAT sequence.