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Furthermore the multiplexed assay enables detection of many proteins at once in one sample, making it a powerful tool for biomarker analysis and early cancer diagnostics.

Akt phosphorylates many proteins at serine/threonine residues that lie in Arg Xaa Arg Xaa Xaa Ser/Thr motifs (where Xaa is any amino acid) and this motif is crucial for the specificity of Akt [25].

Opposing this, Californian lines tended to have reduced expression of many proteins at the heart of mitochondrial function, including ATP synthase β and δ subunits, cytochrome C oxidases, NADH dehydrogenases and malate dehydrogenase, indicating a much lower rate of primary metabolism in the Californian populations compared to the other populations analyzed.

A unique feature of miRNAs is that they act as 'master switches' in the genome by regulating many proteins at the same time, harbouring an enormous potential to be used as therapeutic targets.

It is not clear how these proteins are organized to complete these steps because it is technically difficult to track the movements of many proteins at the same time.

The DNA-damage response (DDR), comprising the sensing, signaling, and repair of damaged DNA, requires recruitment and post-translational modification (PTM) of many proteins at DNA-damage sites (Polo and Jackson, 2011).

Similar(54)

In accordance with this, many proteins identified at TJs are found at other compartments of the cell as well including the nucleus or the cytoskeleton and are actively shuttling between these compartments and the TJs (Matter and Balda 2007).

Many proteins found at FAs participate in the formation of other "adhesive structures" such as the so-called "phagocytic cup".

Furthermore, many proteins found at specific subcellular compartments have been found to possess distinctive amino acid compositions useful for predicting protein localization (Cedano et al., 1997).

Indeed, recent ribosome profiling experiments in yeast suggest that many proteins arrive at the Sec61 translocon before the TMD is exposed (Jan et al., 2014).

We use 50 as a cut-off because that many proteins similar at only the fold level have GDT or uGDT ∼50.

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