These were so explosively, scathingly grotesque and hit out at so many targets as to defy exegesis.
Like many a ruse, this one relies on hitting many, many potential targets at once.
Moreover, at concentrations that induce programmed cell death, many targets are modified at only one or two sites.
While the wealth of BD-related and psychiatric disorder-related research in recent years has identified many targets of lithium at the cellular and molecular levels, even more questions have been raised by these findings.
Transcription factors and microRNAs are both trans-acting regulators of gene expression, which can alter the expression of their many target genes at different levels, the former at the transcriptional level and the latter at the post-transactional level (Hobert, 2004).
The new Apaches not only carry much larger, longer-range Hellfire missiles, but since the gulf war have been equipped with a new Longbow targeting system that can shoot the missiles at many targets simultaneously.
Breslin directs his anger at many targets, including United States immigration policy and the bureaucratic inertia of the city's Buildings Department, but he saves his most venomous attacks for the developers, crooks with blueprints, and the Giuliani administration, which valued their support too highly.
For example, members of the Polycomb group complex, which catalyzes repressive H3K27 methylation at many targets shared with SET1/MLL, have been shown to play important roles in planarian stem cells., Interestingly, flatworms appear to lack DNA methylation altogether (reviewed in ref. 71), and it is possible that modification of histones is the predominant epigenetic process in planarians.
Many trials targeted "at-risk" women, but failed to screen out women with a current disorder.
