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There are too many possible interactions [1] and not enough data to discriminate between various possibilities.
The figure shows only one of the many possible interactions, every one of which is different.
This is more daunting than it seems: scientists have yet to even figure out how the relatively simple, three-hundred-and-two-neuron circuitry of the C. Elegans worm works, in part because there are so many possible interactions that can take place between sets of neurons.
On the other hand, it is fundamental to keep in mind the many possible interactions among antiretroviral drugs when choosing antihypertensive treatment.
The inherent donor acceptor arrangements of the bases support many possible interactions to Asn (or Gln) and Ser (or Thr or Tyr), few interactions to Asp (or Glu) even though several already have been observed, and interactions to U (or T) only if the base is in an unpaired context, as also observed in several cases.
For each experiment we recorded 20000 images taken every 400 ms. We used no more than 10 worms per plate to prevent too many possible interactions between them and to track them easily for a long time.
Similar(52)
(3) The Hp-π interactions are point to π-plane interactions, having many possible interaction conformations.
In the case of Aβ1−40, the highly hydrophobic C-terminal region provides many possible interaction interfaces for 2-fold or 3-fold arrangement patterns.
Also, the relatively low success rate of large-scale epistasis searches to date may simply reflect the limited ability to assess the many possible modes of interaction, including pairwise interactions and threshold effects [27] or inadequate solutions given to a difficult statistical challenge [21].
We therefore believe that this is a dynamic network of interactions and are hesitant to show a detailed static picture that would only reflect one of the many possible sets of interactions as a figure in the main text.
The fact that a single miRNA can engage in many possible miRNA-mRNA interactions can render regulatory networks highly complex.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com