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RITE enables the following of protein dynamics under many physiological conditions.

Central to all the major electron transfer chains are enzymes of the cytochrome (cyt) bc1 complex family, which under many physiological conditions control the flux.

This metabolic plasticity is a built-in feature that allows even normal cells to acquire aerobic glycolysis under many physiological conditions.

Hypoxia can be a consequence in some pathological conditions, such as cardiovascular and cerebral ischemia, inflammation, pulmonary disorders and cancer, as well as in many physiological conditions including high altitude and physical exercise [ 2].

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In addition, a RITE switch does not require specific media changes and is permanent, which allows monitoring of protein dynamics under many different physiological conditions (De Vos et al. 2011; Radman-Livaja et al. 2011; Hotz et al. 2012; Ouellet and Barral 2012; Menendez-Benito et al. 2013).

Hence, L-arginine supplementation has been widely used under many physiological and pathological conditions aiming to improve health status or to treat diseases including cardiovascular diseases [ 2, 4- 7].

Free radicals play important roles in many physiological and pathological conditions [1].

EMT is under tight control of multiple regulatory pathways; first and foremost, transforming growth factor β (TGF-β) signaling activity is enhanced in many physiological and pathological conditions in which EMT is observed, such as organogenesis, inflammation and tumor invasion [7, 8].

The ability of cells to recognize and respond to a low-oxygen environment (hypoxia) is critical in many physiological and pathological conditions [1], [2].

Reactive oxygen species (ROS) can react with DNA, proteins and lipids and play important roles in many physiological and pathophysiological conditions, such as diabetes, neurodegenerative diseases, cancer, and aging [11].

SIRTs have been demonstrated to play important roles in many physiological and pathophysiological conditions, including metabolism, cell survival, cancer, aging and calorie restriction-mediated longevity of organisms ranging from yeasts to humans [21], [22].

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