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The ability to provide oscillatory signals also introduces the possibility of direct investigation of frequency-encoded regulation pathways, which have been implicated in multiple physiological conditions from cardiac hypertrophy to oocyte fertilization [5].
The UPR is considered an efficient cellular mechanism of adaptation to multiple physiological conditions, but it has also been implicated in the physiopathology of various diseases [ 86, 88– 90].
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Noninvasive strength assessment techniques are the clinical standard in the diagnosis and treatment of osteoporotic vertebral fractures, and the efficacy of these protocols depends on their ability to predict vertebral strength at all at-risk spinal levels under multiple physiological loading conditions.
Additionally, a cDNA library from whole plants subjected to multiple physiological stress conditions was generated (StsL) (see Methods for more details).
Two FLX pyrosequencing runs were performed (the pico-titer plate was divided in two sectors), 1/2 run from StsL (cDNA pool obtained from U. gibba plants exposed to multiple physiological stress condition; stress Library), 1/2 run for ShtL (shoots library), 1/2 run for FlwL Inflorescences library) and 1/2 run for TrpL (utricles or traps Library).
ATX and LPA1 3 receptors are expressed in mammary glands and can exert multiple effects under physiological conditions [7], [8].
The 28 kDa and 24 kDa SMP30 forms were also detected in normal rat liver suggesting that SMP30 does exist in multiple forms under physiological conditions.
The 28 kDa and 24 kDa SMP30 forms were also detected in normal rat liver and mice injected with Ad-SMP30-HA suggesting that SMP30 does exist in multiple forms under physiological conditions.
This new discovery provides opportunities for additional research of the function of this distinct pathway in the multiple physiological and pathological conditions regulated by relaxin.
Multiple physiological and pathological conditions, including the accumulation of misfolded proteins, such as insulin or human IAPP (hIAPP), are responsible for the loss of ER homeostasis in β-cells.
In the absence of a clear proteolytic activity of SERAser proteins under physiological conditions, multiple non-catalytic cellular roles, including regulatory functions, have to be considered.
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