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Exact(9)
The estimated networks also recover many known interactions between genes.
Ascorbic acid has many known interactions with metal ions, catalysing its oxidation with concomitant formation of hydrogen peroxide, among other things.
LMML also inferred many known interactions along with a relatively large number of interactions which could not be supported by literature evidence.
The subnetwork diagrams indicate that models recapitulate many known interactions in pathways, which are important in melanoma tumorigenesis (e.g., PI3K/AKT and ERK) and nominate previously unidentified interactions (see Figure 4 legend).
For instance, Y2H maps of human mitogen-activated protein kinase (MAPK) signaling network not only confirmed many known interactions but also revealed many new roles for chaperons and proton pumps in the regulation of MAPK functions [ 46].
While there are many computational techniques proposed for this network reconstruction task, their accuracy is consistently limited by the small number of high-confidence examples, and the uneven distribution of these examples across the potential interaction space, with some objects having many known interactions and others few.
Similar(51)
The described biological effects are, in contrast to many other known interactions, receptor mediated and therefore very specific for certain cell types.
Stochastic MRA inferred many well known interactions (represented by black lines in Figure 6(b)) which take part in the ERBB2 mediated G1/S transition control mechanism.
Limits: To provide a good mapping of the adaptive landscape at this level, one either needs a thorough mechanistic understanding of the corresponding fitness correlates or a firm grasp of a general theory that allows for reasonable predictions in the presence of many poorly known interactions.
Many of these known interactions are confined to the few TFs for which ChIP-chip data is available (see Methods).
In the area of many known multielement interactions, the zinc (Zn)–cadmium (Cd) interaction may appear hormetic, inducing biosynthesis of metallothionein (MT) and binding of Cd to yield the Cd MT complex.
Related(20)
multiple known interactions
many known reactions
several known interactions
many known relationships
many well known interactions
many known causes
many known carcinogens
many known benefits
many known Causes
many known complexes
many known networks
many known diseases
many known opponents
many known substrates
many known unknowns
many known facts
many known ligands
many known NATs
many known limitations
many known oilfields
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