Sentence examples for many genes particularly from inspiring English sources

Many reports have also shown that aberrant methylation of CpG islands leads to inactivation of many genes, particularly in gastric cancers (24– 24).

This binding increases the transcription of many genes, particularly those encoding signaling molecules (e.g., chemokines and cytokines) and enzymes (e.g., oxidases and proteases) (figure 3).

In addition, histologic tumour type-related differences in methylation have been documented in many genes, particularly tumour suppressor genes (Kim et al, 2004).

Three families of MAPK including c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 regulate many genes particularly those of the inflammatory and immune response [ 19].

While this may not always be true it is reasonable to expect this for the many genes particularly with immune related functions which require rapid responses of cells to external stimuli and their rapid return to a resting state in the absence of the stimuli.

Increased expression of the transcription factor, HIF-1 α, in tumor cells is a hallmark of hypoxia, and HIF-1 α plays a central role promoting tumor cell survival and growth during hypoxic conditions by changing the expression profile of many genes particularly angiogenic factors such as VEGF [ 39, 40].

Many genes, and particularly regulatory genes, are utilized multiple times in unrelated phases of development.

No experimental evidence about the utility of LLTCK in monocot plants has been published so far; it should be noted however that, although not in association between each other, CT- and GA-rich regions occur in the proximity of the transcription start site of many plant genes, particularly in monocots (Chen et al.1996).1996

17, 22, 23 This type of study has been successful in identifying many disease genes, particularly those that cause Mendelian traits, but less successful in identifying genes associated with complex diseases.

In addition, for many PGx genes (particularly variants in genes coding for enzymes) the overall phenotype is derived from a diplotype, which is the combination of variants or haplotypes on both alleles.

Indeed, many Aquificae genes, particularly those with metabolic functions, are related to the Archaea, particularly the Euryarchaeota, and were likely acquisitions enabling differing strategies for ecological adaptation, such as the bd-type complex IV of oxidative phosphorylation, which may confer adaptation to low oxygen concentrations.