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Exact(8)
Together, the data suggest design principles relevant to many developing tissues.
Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues.
In many developing tissues, signaling mediated by activation of the transmembrane receptor Notch influences cell-fate decisions, differentiation, proliferation, and cell survival.
The RNA-binding proteins Lin28 and Lin28b are expressed in many developing tissues and are involved in the biosynthesis of the microRNA let-7 family and embryogenesis processes.
Many developing tissues display regenerative capability that allows them to compensate cell loss and preserve tissue homeostasis.
In many developing tissues, pattern formation depends on the differential regulation of gene expression by morphogen gradients (Kicheva et al., 2012; Rogers and Schier, 2011).
Similar(52)
The mechanisms connecting them all are unknown but many similarities exist between different developing tissues suggesting a common mechanism.
Dicer1, an essential component of RNA interference and the microRNA pathway, has many important roles in the morphogenesis of developing tissues.
In fact, similarities between developing tissues and tumor tissues are demonstrated by higher concentrations of HA in many malignant tumors than in corresponding benign tumors or normal tissues [18], [19], [20].
The protein is expressed in the developing tissues and fluoresces under illumination.
While diffusive transport effects on morphogenesis are well illustrated in examples like blood capillary architecture and in cell morphogenetic responses to the local extracellular protein environment, the effects of fluid convection, although important in many developing and regenerating tissues, are not well understood.
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