Sentence examples for many chromosomal abnormalities from inspiring English sources

In addition, many chromosomal abnormalities are important indicators of prognosis and are used to determine treatment strategies (Wheatley et al, 1999).

Neuroblastoma (NB) is a tumour in which many chromosomal abnormalities have been detected (Takita et al, 1995; Mora et al, 2002a).

Traditional chromosome analyses provided important information on chromosomal aberrations in pancreatic cancer and revealed a high degree of ploidy with many chromosomal abnormalities [ 21].

HNSCCs also exhibit many chromosomal abnormalities, including amplifications of the 11q13 region containing the cyclin D1 gene and the 7p11 region encoding EGFR, which lead to proto-oncogene activation.

Since that study, many chromosomal abnormalities in AL patients using cIg-FISH have been described, such as translocations involving 14q32, t(11 14), t(4 14) and monosomy 13/deletion 13/deletion

Our observation that lymphocytes and PCs in the same aspirate share chromosomal abnormalities provide evidence for a lineage relationship between these two compartments of the MM clone, suggesting that many chromosomal abnormalities may arise in lymphocytes and are passed to their PC progeny or the unlikely possibility that a subset of MM-PC reverts to lymphocyte morphology.

Many recurrent chromosomal abnormalities are caused by nonallelic homologous recombination (NAHR) mediated by flanking segmental duplications.

This database covers the majority of the most commonly encountered chromosomal conditions in clinical practice, as well as many rarely seen chromosomal abnormalities.

Whilst many of such rearrangements may result in spontaneous abortions (as many as 50% of human reproductive failures could be due to chromosomal abnormalities), many others will be viable, as testified by the fact that as many as one in 625 phenotypically healthy human beings carries a reciprocal chromosomal translocation [ 54].

Many studies have identified chromosomal abnormalities in iPSCs, indicating that reprogramming itself can induce genetic instability.

PCs had from only one to as many as eight distinct chromosomal abnormalities.